Advancing Innovative Therapies Across Neurology and Neuropsychiatry to Address Critical Unmet Needs

THERAPEUTIC PIPELINE

Target Indication*
D2/D3 Partial Agonist,
5-HT2A Antagonist
Schizophrenia
GABAAR PAM Tinnitus
Uncompetitive GAT-1 Inhibitor Focal Epilepsy
PDE9 Inhibitor Cognitive impairment associated with hepatic encephalopathy and other reversible encephalopathies

TRTL-107

D2/D3 Partial Agonist, 5-HT2A Antagonist

Schizophrenia

DISCOVERY PRECLINICAL PHASE I PHASE II PHASE III

TRTL-913

GABAAR PAM

Tinnitus

DISCOVERY PRECLINICAL PHASE I PHASE II PHASE III

TRTL-729

Uncompetitive GAT-1 Inhibitor

Focal Epilepsy

DISCOVERY PRECLINICAL PHASE I PHASE II PHASE III

TRTL-118

PDE9 Inhibitor

Cognitive impairment associated with hepatic encephalopathy and other reversible encephalopathies

DISCOVERY PRECLINICAL PHASE I PHASE II PHASE III

Discovery

DISCOVERY PRECLINICAL PHASE I PHASE II PHASE III

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DISCOVERY PRECLINICAL PHASE I PHASE II PHASE III PARTNER

TRTL-107

TRTL-913

TRTL-729

TRTL-118

Discovery

*While development is currently focused on lead indications, we intend to evaluate additional patient populations to expand each asset’s potential.